In an experiment by Bruno Chausse, Bruno addressed the effects of intermittent fasting on redox state markers in different tissues in order to discern how changes in feeding frequency alter redox balance in rats.

Redox (reduction and oxidation): a chemical reaction between two substances in which one substance is oxidized and the other reduced

The results were that “intermittent fasting for rats displayed lower body mass due to decreased energy conversion efficiency… Livers in rats presented increased mitochondrial respiratory capacity and enhanced levels of protein carbonyls.”

Interestingly, the intermittent fasting for these animals actually showed an increase in the oxidative damage in the brain.  This damage was not related to changes in mitochondrial bioenergetics.

However,  intermittent fasting actually proved to be a “substantial” protection against any oxidative damage in the heart.  There was no difference observed in either mitochondrial bioenergetics or redox homeostasis in skeletal muscles from intermittent fasting in the rodents.

The overall conclusion was that intermittent fasting seems to affect the redox balance in a tissue-specific manner in rats, which leads to redox imbalance in both the liver and the brain, but actually promotes a kind of protection against oxidative damage in the heart.

Bioenergetics:  the biology of energy transformations and energy exchanges (as in photosynthesis) within and between living things and their environments

The question that is left unanswered in this study is the question of how intermittent fasting specifically effects humans concerning their bioenergetics and redox state.  This question is something that must be answered. However, only further research and studies can confirm an answer.



Chausse, Bruno, et al. “Intermittent Fasting Results in Tissue-Specific changes in Bioenergetics and Redox State.” PLoS ONE,, vol. 10, no. 3, 2015.  Health&Wellness Resource Center,